4Evidence Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.3Servicio de Clinica Médica del Hospital Alemán, Buenos Aires, Argentina.2Department of Medicine, McMaster University, Hamilton, ON, Canada.1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.Romina Brignardello-Petersen, methodologist1.Gordon H Guyatt, methodologist, internist 1 2,.Ying Wang, methodologist, pharmacist 1,.Robin WM Vernooij, methodologist 17 18,.Per O Vandvik, methodologist, internist 16,.Charlotte Switzer, graduate student 1,.Bram Rochwerg, methodologist, critical care physician 1 2,.Reem A Mustafa, associate professor, nephrologist 1 15,.Srinivas Murthy, clinical associate professor, pediatric critical care, infectious diseases physician 14,.Anna Miroshnychenko, graduate student 1,.Mark Loeb, methodologist, infectious disease physician 1 2,.Francois Lamontagne, methodologist, critical care physician 13,.Derek K Chu, methodologist, immunologist 1 2,.Donald Arnold, professor of hematology 2,.Thomas Agoritsas, methodologist, internist 1 6,.Sophia Mangala, research assisstant 1,.Ariel Izcovich, methodologist, internist 3,.Juan Pablo Díaz Martinez, statistician 1 *,.Jessica J Bartoszko, methodologist 1 *,.Reed AC Siemieniuk, methodologist, internist 1 2 *,.These findings suggest that therapeutic approaches targeting the GC stroma may merit evaluation.īarrett's carcinoma Barrett's metaplasia Gastric cancer Helicobacter pylori–gastritis carcinogenesis colorectal cancer colorectal cancer screening gastric adenocarcinoma gastric pre-cancer gene expression hepatoma image analysis liver molecular pathology oesophageal cancer prognostic factors. Stromal gene expression predicts GC patient survival in multiple independent cohorts, and may be closely related to the intra-tumoural stroma proportion, a specific morphological GC phenotype. The proportion of intra-tumoural stroma, quantified by morphometry in tissue sections from gastrectomy specimens, was also significantly associated with stromal super-module expression and GC patient survival. Expression of a transforming growth factor β (TGF-β) signalling associated 'super-module' of stroma-related genes consistently predicted patient survival in multiple GC validation cohorts. The authors identified 178 gene expression programmes ('modules') expressed in primary GCs, which were associated with distinct biological processes, chromosomal location patterns, cis-regulatory motifs and clinicopathological parameters. The authors analysed a training set of 428 GCs and 163 non-malignant gastric samples, and a validation set of 288 GCs and 61 non-malignant gastric samples. Using a network-modelling approach, the authors performed a large-scale meta-analysis of GC transcriptome data integrating 940 gastric transcriptomes from multiple independent patient cohorts. The authors aimed to produce a comprehensive inventory of gene expression programmes expressed in primary GCs, and to identify those expression programmes significantly associated with patient survival. Identifying molecular programmes contributing to GC patient survival may improve our understanding of GC pathogenesis, highlight new prognostic factors and reveal novel therapeutic targets. Gastric adenocarcinoma (gastric cancer, GC) is a major cause of global cancer mortality.
0 kommentar(er)
